Journal of Diabetes Research / 2012 / Article / Tab 1

Research Article

BDKRB2 +9/−9 Polymorphism Is Associated with Higher Risk for Diabetes Mellitus in the Brazilian General Population

Table 1

Demographic, clinical, and biochemical data according to genotypes for the BDKRB2 polymorphism.

Subject Characteristics+9/+9 /+9/−9−9/−9 value

n, (%)845 (80.2%)208 (19.8%)

Gender, male386 (45.7%)99 (47.6%)0.62
Ethnicity, n (%)
 African descent81 (9.6%)17 (8.2%)0.63
 Caucasian descent493 (58.3%)126 (60.6%)
 Mullato256 (30.3%)59 (28.4%)
 Others15 (1.8%)6 (2.9%)
Diabetes, n (%)64 (7.6%)8 (3.6%)0.03
Obesity, n (%)183 (24.4%)41 (21.6%)0.41
Age, years42.7 ± 14.144.4 ± 15.20.12
BMl*, kg/m227.0 ± 5.126.4 ± 4.80.19
Abdominal Circumference, cm90.5 ± 13.690.4 ± 13.30.90
SBP, mmHg128.6 ± 23.4126.2 ± 22.10.13
DBP, mmHg80.1 ± 14.378.4 ± 12.40.07
Glucose, mg/dL84.5 ± 28.380.6 ± 21.90.04
Triglycerides, mg/dL154.2 ± 86.4146.9 ± 71.20.33
Total cholesterol, mg/dL193.4 ± 35.4187.7 ± 33.2 0.13

OR [95% CI], value
Diabetes Mellitus
UnadjustedAdjusted

Genetic Models of Inheritance +9/+9/+9/−9 genotype group2.05 [0.97–4.34] 1.91 [1.09–4.19]
0.060.03

*Adjusted for gender and age.
Adjusted for gender, age, and BMI.
BMI: body mass index; SBP: systolic blood pressure; DBP: diastolic blood pressure.
“Race/color” was classified according to Brazilian Census as White, Intermediate (meaning Brown, Pardo in Portuguese), or Black.