BDKRB2 +9/−9 Polymorphism Is Associated with Higher Risk for Diabetes Mellitus in the Brazilian General Population
Table 1
Demographic, clinical, and biochemical data according to genotypes for the BDKRB2 polymorphism.
Subject Characteristics
+9/+9 /+9/−9
−9/−9
value
n, (%)
845 (80.2%)
208 (19.8%)
Gender, male
386 (45.7%)
99 (47.6%)
0.62
Ethnicity, n (%)
African descent
81 (9.6%)
17 (8.2%)
0.63
Caucasian descent
493 (58.3%)
126 (60.6%)
Mullato
256 (30.3%)
59 (28.4%)
Others
15 (1.8%)
6 (2.9%)
Diabetes, n (%)
64 (7.6%)
8 (3.6%)
0.03
Obesity, n (%)
183 (24.4%)
41 (21.6%)
0.41
Age, years
42.7 ± 14.1
44.4 ± 15.2
0.12
BMl*, kg/m2
27.0 ± 5.1
26.4 ± 4.8
0.19
Abdominal Circumference, cm
90.5 ± 13.6
90.4 ± 13.3
0.90
SBP†, mmHg
128.6 ± 23.4
126.2 ± 22.1
0.13
DBP†, mmHg
80.1 ± 14.3
78.4 ± 12.4
0.07
Glucose†, mg/dL
84.5 ± 28.3
80.6 ± 21.9
0.04
Triglycerides†, mg/dL
154.2 ± 86.4
146.9 ± 71.2
0.33
Total cholesterol†, mg/dL
193.4 ± 35.4
187.7 ± 33.2
0.13
OR [95% CI], value
Diabetes Mellitus
Unadjusted
Adjusted†
Genetic Models of Inheritance +9/+9/+9/−9 genotype group
2.05 [0.97–4.34]
1.91 [1.09–4.19]
0.06
0.03
*Adjusted for gender and age. †Adjusted for gender, age, and BMI. BMI: body mass index; SBP: systolic blood pressure; DBP: diastolic blood pressure. “Race/color” was classified according to Brazilian Census as White, Intermediate (meaning Brown, Pardo in Portuguese), or Black.
