Topical Application of Sadat-Habdan Mesenchymal Stimulating Peptide (SHMSP) Accelerates Wound Healing in Diabetic Rabbits

Figure 1

(A, B, and C) Photomicrograph of a skin section from control group showing (A) nonhealed ulcer (arrows). There is dermoepidermal separation due to presence of marked inflammatory cell infiltration (I). The epidermal cells on the left side of the photo are replaced by inflammatory cells (Ic), and those on the right side of the photo show cytoplasmic vacuolation (V) and pyknosis (P) of some of their nuclei. (H&E ×200). (B) Incomplete healing of the ulcer (arrow) due to presence of marked inflammatory cell infiltration (I). The epidermal cells on both sides of the ulcer area show marked increase in thickness (acanthosis), and lots of them appeared vacuolated (V). Note also the presence of parakeratosis (P; presence of nuclei in keratin layer), (H&E ×200). (C) High-power view of the previous photo. There is marked increase in epidermal thickness on both sides of the ulcer area, marked cellular infiltration (I), parakeratosis (P), and vacuolated epidermal cells (V). Some of the epidermal cells also show pyknosis (Py) or karyolysis (K) of their nuclei (H&E ×400). (D) Photomicrograph of a skin section from the peptide group showing complete healing of the ulcer and normal appearance of both the epidermis (E) and dermis (papillary dermis; P and reticular dermis; R). Note also that some of the epidermal cells show mitotic figures (arrow) (H&E ×400).