New Experimental Models of Diabetic Nephropathy in Mice Models of Type 2 Diabetes: Efforts to Replicate Human Nephropathy

Figure 2

Glomerular histopathology in eNOS^−/− db/db mice. Representative glomerular lesions of diabetic mouse kidneys at 24–26 wk: control (a); db/db (b and e); eNOS^−/− (c) eNOS^−/− db/db (d and f). (f) Arteriolar hyalinosis (big arrow) and early nodular glomerulosclerosis (small arrow) in eNOS^−/− db/db mice (periodic acid-Schiff). Reprinted with permission from the Journal of the American Society of Nephrology [25].