Modulation of Apoptosis Pathways by Oxidative Stress and Autophagy in β Cells

Table 1

Functional grouping of apoptosis pathway genes.

Bcl-2 family	BAD, BAG1, BAG3, BAG4, BAK1, BAX, BCL2, BCL2A1, BCL2L1, BCL2L10, BCL2L11, BCL2L2, BCLAF1, BID, BIK, BNIP1, BNIP2, BNIP3, BNIP3L, HRK, MCL1
Caspase family	CASP1, CASP10, CASP14, CASP2, CASP3, CASP4, CASP5, CASP6, CASP7, CASP8, CASP9
IAP family	BIRC1, BIRC2, BIRC3, BIRC4, BIRC6, BIRC8
TRAF family	TRAF2, TRAF3, TRAF4
CARD family	APAF1, BCL10, BIRC2, BIRC3, CARD4, CARD6, CARD8, CASP1, CASP2, CASP4, CASP5, CASP9, CRADD, NOL3, PYCARD, RIPK2
Death domain family	CRADD, DAPK1, FADD, FAS (TNFRSF6), TNFRSF10A, TNFRSF10B, TNFRSF11B, TNFRSF1A, TNFRSF21, TNFRSF25, TRADD
Death effector domain family	CASP8, CASP10, CFLAR, FADD
CIDE domain family	CIDE-A, CIDE-B, DFFA
p53 and DNA damage response	ABL1, AKT1, APAF1, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, GADD45A, TP53, TP53BP2, TP73
Anti-apoptosis	AKT1, BAG1, BAG3, BCL2, BCL2A1, BCL2L1, BCL2L10, BCL2L2, BFAR, BIRC1, BIRC2, BIRC3, BIRC4, BIRC6, BIRC8, BNIP1, BNIP2, BNIP3, BRAF, CFLAR, IGF1R, MCL1, TNFRSF7
TNF ligand family	CD40LG (TNFSF5), FASLG (TNFSF6), LTA, TNF, TNFSF10, TNFSF7, TNFSF8
TNF receptor family	CD40 (TNFRSF5), FAS (TNFRSF6), LTBR, TNFRSF10A, TNFRSF10B, TNFRSF11B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF7, TNFRSF9