Combined Transfection of the Three Transcriptional Factors, PDX-1, NeuroD1, and MafA, Causes Differentiation of Bone Marrow Mesenchymal Stem Cells into Insulin-Producing Cells
Figure 7
Immunohistochemistry assay for insulin of the survival infected mMSCs in the liver tissues of mice with diabetes. (a) Positive control, anti-mouse insulin staining of mouse pancreatic specimen showing an intense expression of insulin (enlargement ×100). (b) Anti-mouse insulin staining of pancreatic specimen of mice with STZ-induced diabetes showing a markedly decreased expression of insulin (enlargement ×100). (c) Infected mMSCs were injected into the livers of mice with diabetes three days after infection. The positive staining of mouse insulin expression can be clearly observed in the liver. (d) An enlargement of induced IPCs in the liver.
