Cellular Dysfunction in Diabetes as Maladaptive Response to Mitochondrial Oxidative Stress

<table>Uncoupling proteins (UCPs) respond to hyperglycemia-induced overproduction of mitochondrial superoxide by catalyzing mild uncoupling, which lowers membrane potential (<svg height="11.6375" id="M4" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 36.762501 11.6375" width="36.762501" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg>) and decreases superoxide production by mitochondrial complex I and III of the electron transport chain. Antioxidants limit the impact of superoxide production on molecular oxidative damage (for more details, see text). MS: mitochondrial redox shuttles; <svg height="17.65" id="M5" style="vertical-align:-3.276pt" version="1.1" viewbox="0 0 32.987499 17.65" width="32.987499" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg>: superoxide radical; PT: pyruvate transporter; TCA: tricarboxylic acid cycle.</table>

Journal of Diabetes Research

fig1

Figure 1

Figure 1: Cellular Dysfunction in Diabetes as Maladaptive Response to Mitochondrial Oxidative Stress 