Cellular Dysfunction in Diabetes as Maladaptive Response to Mitochondrial Oxidative Stress
Figure 1
Uncoupling proteins (UCPs) respond to hyperglycemia-induced overproduction of mitochondrial superoxide by catalyzing mild uncoupling, which lowers membrane potential () and decreases superoxide production by mitochondrial complex I and III of the electron transport chain. Antioxidants limit the impact of superoxide production on molecular oxidative damage (for more details, see text). MS: mitochondrial redox shuttles; : superoxide radical; PT: pyruvate transporter; TCA: tricarboxylic acid cycle.
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