Angiotensin-Converting Enzyme Genotype and Peripheral Arterial Disease in Diabetic Patients
Table 3
Gene transmission models for insertion/deletion (I/D) polymorphism of angiotensin-converting enzyme gene on peripheral arterial disease.
Gene transmission
chi-square test
Logistic regression*
Total
Peripheral arterial disease, (%)
value
Adjusted odds ratio (95% confidence interval)
value
Akaike information criterion
No
Yes
Recessive model
II/ID
857
788 (91.9)
69 (8.1)
1.00
DD
88
76 (86.4)
12 (13.6)
0.075
2.48 (1.18–5.21)
0.017
425.880
Dominant model
II
465
430 (92.5)
35 (7.5)
1.00
ID/DD
480
434 (90.4)
46 (9.6)
0.259
1.69 (1.00–2.85)
0.050
427.157
Additive model
II = 0,
465
430 (92.5)
35 (7.5)
1.00
ID = 1,
392
358 (91.3)
34 (8.7)
1.64 (1.12–2.39) per risk
DD = 2
88
76 (86.4)
12 (13.6)
0.171
allele
0.010
424.612
*Adjusted variables include age, sex, body mass index, duration of diabetes, hemoglobin , uric acid, ln[lipoprotein (a)], hypertension, smoking, and dyslipidemia.
