Effect of Exercise on Kidney Function, Oxidative Stress, and Inflammation in Type 2 Diabetic KK-A^y Mice

Figure 2

HIF-1α staining intensity and staining in KK-𝐴^𝑦 mice with and without exercise at 20 weeks of age. HIF-1α staining intensity in moderate-intensity exercised KK-𝐴^𝑦 mice was significantly enhanced compared with that in the sedentary KK-𝐴^𝑦 mice, but these levels did not differ between sedentary and low-intensity exercised KK-𝐴^𝑦 mice. ^∗𝑃<0.001. Representative HIF-1α staining in the renal cortex of sedentary KK (b, g), sedentary KK-𝐴^𝑦 (c, h), low-intensity exercised KK-𝐴^𝑦 (d, i), and moderate-intensity exercised KK-𝐴^𝑦 mice. (e, j) Staining (a, f) depicts the absence of primary antibody. Images (a–e) were taken at 40-fold magnification and images (f–j) were taken at 400-fold magnification. ^∗𝑃<0.001.