Effect of Exercise on Kidney Function, Oxidative Stress, and Inflammation in Type 2 Diabetic KK-A^y Mice

Figure 4

Number of CD68 and CD204 positive cells and staining in each mouse at 20 weeks of age. Bar charts show CD68 and CD204 positive cells in the glomeruli and tubulointerstitial area of sedentary KK (b), sedentary KK-𝐴^𝑦 (c), low-intensity exercised KK-𝐴^𝑦 (d), and moderate-intensity exercised KK-𝐴^𝑦 mice. (e) The number of CD68 positive cells in glomeruli of sedentary KK-𝐴^𝑦 mice were significantly greater compared with that of sedentary KK mice, but it did not differ between sedentary and exercised KK-𝐴^𝑦 mice. The number of CD68 positive cells in glomeruli of sedentary KK-𝐴^𝑦 mice was significantly greater compared with that of sedentary KK mice and also low-intensity exercised KK-𝐴^𝑦 mice, but not moderate-intensity exercised KK-𝐴^𝑦 mice. The number of CD68 positive cells in the tubulointerstitial area of sedentary KK-𝐴^𝑦 mice was significantly greater compared with that of sedentary KK mice and also exercised KK-𝐴^𝑦 mice, but it did not differ between low- and moderate-intensity exercised KK-𝐴^𝑦 mice. The number of CD204 positive cells in tubulointerstitial area of sedentary KK-𝐴^𝑦 mice was significantly greater compared with that of sedentary KK mice, but it did not differ between sedentary and exercised KK-𝐴^𝑦 mice. ^∗𝑃<0.05^†𝑃<0.01^‡𝑃<0.001.