The Common C49620T Polymorphism in the Sulfonylurea Receptor Gene SUR1 (ABCC8) in Patients with Gestational Diabetes and Subsequent Glucose Metabolism Abnormalities

Table 4

Relationships between the polymorphism C49620T in the SUR1 (ABCC8) gene and glucose metabolism parameters, 𝛽-cell function, and insulin resistance in the GDM (+) group.

Parameter	CC; Mean ± SD (n = 54)	CT; Mean ± SD (n = 96)	TT; Mean ± SD (n = 49)	P value; CC versus CT	P value; CT versus TT	P value; CC versus TT
Glucose 0^′ (mmol/L)	5.3 ± 0.8	5.3 ± 0.7	5.4 ± 0.7	NS	NS	NS
Glucose 60^′ (mmol/L)	7.9 ± 2.3	8.5 ± 2.7	8.4 ± 2.5	0.0121	NS	NS
Glucose 120^′ (mmol/L)	6.2 ± 2.1	6.6 ± 2.3	6.2 ± 2.1	NS	NS	NS
Insulin 0^′ (𝜇IU/mL)	12.5 ± 6.1	13.6 ± 8.5	15.0 ± 11.2	NS	NS	NS
Insulin 60^′ (𝜇IU/mL)	96.7 ± 43.9	109.9 ± 64.1	112.0 ± 76.4	NS	NS	NS
Insulin 120^′ (𝜇IU/mL)	64.3 ± 48.6	78.4 ± 54.4	78.5 ± 75.4	0.0483	NS	NS
HbA1c (%)	5.6 ± 0.5	5.7 ± 0.4	5.7 ± 0.4	NS	NS	NS
HOMA IR	1.63 ± 0.80	1.77 ± 1.08	1.91 ± 1.22	NS	NS	NS
HOMA %B	121.9 ± 48.0	126.3 ± 51.9	126.8 ± 60.1	NS	NS	NS
HOMA %S	77.4 ± 46.3	71.2 ± 31.6	69.1 ± 41.8	NS	NS	NS