Beneficial Effects of Aminoguanidine on Skin Flap Survival in Diabetic Rats
Figure 3
Light microscopy of the skin flaps (Masson’s trichrome stain). Control group (a, e, i), AG group (b, f, j), DM group (c, g, k), DM + AG group (d, h, l). Comparison of hair follicles among the four groups (a, b, c, d), comparison of fibroblasts among the four groups (e, f, g, h), comparison of inflammation among the four groups (i, j, k, l). In the AG group (b, f), in the number of hair follicles (MT ×100) and in the cytological appearance of the fibroblasts (MT ×400), no significant difference was observed when compared to the control group (a, e). In the DM group (c), a significant decrease in the number of hair follicles (MT ×100) and dermal atrophy features including reduced dermal thickness, cytologically more rounded appearance of fibroblasts (MT ×400), and slightly irregular collagen structure was observed when compared to the control group (e). Inflammation and necrosis were more apparent in the DM groups (k, l) (MT ×100).
