Beneficial Effects of Aminoguanidine on Skin Flap Survival in Diabetic Rats

Table 1

Necrosis area of groups (%) ± standard deviation (SD) and MDA, NO, GSH, and SOD activity levels of the flap tissue and 𝑃≤0.05 values.

Groups	Necrosis area (%)	MDA (nmol/g tissue)	NO (nmol/g tissue)	SOD (U/g protein)	GSH (nmol/g tissue)
(I) Control	50,9 ± 0,13	25,14 ± 12,92	150,19 ± 18,66	4,66 ± 1,72	0,96 ± 0,11
(II) AG	32,9 ± 0,12	21,99 ± 10,05	120,93 ± 10,85	6,80 ± 1,30	1,31 ± 0,20
(III) DM	65,2 ± 0,11	100,74 ± 83,19	203,75 ± 11,26	2,72 ± 0,47	0,68 ± 0,08
(IV) DM + AG	43,5 ± 0,14	45,22 ± 27,20	159,58 ± 16,00	5,75 ± 0,96	0,90 ± 0,11
Comparisons of the groups	P values*
I-II	0.001		0.001	0.009	0.001
I–III	0.001	0.009	0.001	0.003	0.001
I–IV		0.023		0.050
II-III	0.001	0.005	0.002	0.002	0.002
II–IV		0.020	0.003		0.005
III-IV	0.003		0.004	0.004	0.010

* Statistically significant values.