Expression of Endoplasmic Reticulum Stress-Related Factors in the Retinas of Diabetic Rats

Table 3

Q-PCR arrays showed that the expression of the ER stress factor had significant differences in the first and the third month in diabetic rat retina: the ER stress factor of significant differences belongs to different ER stress signaling pathways.

Signaling pathway	First month	Third month
Unfolded protein binding	Cctd, ERdj4, Hspt70-3	ERdj4, OMI/PARK13, CYPA, HUGT1
ER protein folding quality control	GluII, PDIA10	HUGT1
Regulation of cholesterol Metabolism	—	SREBP1
Regulation of translation	—	—
ERAD	Herp, NUC, Os9, ADO15	Herp, OMI/PARK13, Hrd1
Ubiquitination	Herp	Herp, UfD1, TGT
Transcription factors	—	ATF4, SREBP1
Protein folding	Cctd, ERdj4,  APG-1, PDIA10	ERdj4, Ero1l, CYPA
Protein disulfide isomerization	PDIA10	SREBP1
Heat shock proteins	ERdj4, P58IPK, Hspt70-3	ERdj4
Apoptosis	JNK/JNK1, Casp12	OMI/PARK13, NIPK/Trib3