Inhibition of Aldose Reductase Activates Hepatic Peroxisome Proliferator-Activated Receptor-α and Ameliorates Hepatosteatosis in Diabetic db/db Mice
Figure 2
Effect of zopol treatment or AR knockdown on hepatic lipid in db/db mice. (a) Oil-red O staining of liver tissues of db/db mice after zopol treatment. (A) db/m; (B) db/m + zopol; (C) db/db; (D) db/db + zopol; (E) db/db + pLV-shNC; (F) db/db + pLV-shAR. Results are typical for 3 mice/group. Original magnification, ×100. (b) AR inhibition or AR knock-down reduced liver TG of db/db mice as analyzed chemically. Lean control mouse groups are db/m () and db/m + zopol (); diabetic mouse groups are db/db (); db/db + zopol () and db/db + pLV-shNC (); db/db + pLV-shAR (). Values are expressed as the mean ± SEM. *; ***.
