Oxidative Metabolism Genes Are Not Responsive to Oxidative Stress in Rodent Beta Cell Lines
Gene expression in INS-1 cells cultured in low (5.6 mmol/L), ambient (11 mmol/L), and high (28 mmol/L) glucose concentrations for 48 hours (gene name above each graph). Gene expression changes were analyzed using TLDA expression profiling on a panel of 90 target genes. Gene expression differences were statistically analyzed by the Kruskal-Wallis H test and were normalized to the mean expression of the endogenous controls B2m and Tbp, as they were found to be most stable using the GeNorm algorithm (Statminer, Integromics). Note that the scales of the graphs differ between genes as the expression is shown relative to mean expression across all genes. Significant results () are indicated by*.
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