Journal of Diabetes Research / 2012 / Article / Tab 1

Research Article

Oxidative Metabolism Genes Are Not Responsive to Oxidative Stress in Rodent Beta Cell Lines

Table 1

Panel of 90 target genes for analysis by TLDA expression profiling. Candidate genes have been shown by pathway-based microanalysis to be deregulated in T2D skeletal muscle, are reported in the literature to be involved in oxidative metabolism or the oxidative stress response, or are reported in the literature to be key players in diabetes pathways/deregulated in T2D.

Panel of 90 target genes for analysis by TLDA expression profiling

Deregulated in T2D skeletal muscleAlas1 Atp5c1 Atp5g1 Atp5g2 Atp5g3 Ckmt1 Cox4i1
Cox6a1 Cox6c Nrf1 Pdx1 Pkm2 Por Sdhc
Slc25a4 Ucp2 Uros Eif2ak3 Sdhb Uqcrc1 Cox5b
Atp5oCox7b Cyc1 Atp5j Ndufa5 Ndufa8 Ndufb5
Ndufb6 Ndufs2 Ndufs3 Ppara Ppard Pparg Ppargc1a
Sdha

Involved in oxidative metabolism and the oxidative stress responseAco1 Ccng1 Cdkn1a Cxcl10 Ddit3 Dnaja1 Fmo1
Gck Gsr Hspa4 Hspa5 Igfbp2 Il18 Ins1
Ireb2 Nfkb1 Nfkbia Pck1 Rad23a Sod1 Tnf
Tp53 Txn2 Txnip Ung Xbp1 Ercc1Mtor
NamptNdufaf1Nfe2l2PrkcdPrkczShc1

Key players in T2D pathways

Cell cycle and apoptosisCrls1Hdac4Hdac5HgfIgf1Suv39h1
Cellular and energy metabolism and homeostasis, including glucose homeostasisFoxo1Gckr HaghHk1Prkaa2Sirt1
Immune and inflammatory processesCrpIl1bIl1rnIl6Rage
Insulin signaling and homeostasisGcgInsrKcnj11

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