Research Article
Genetic Variation in CYP17A1 Is Associated with Arterial Stiffness in Diabetic Subjects
Table 1
Clinical and biochemical parameters of prediabetic and diabetic subjects.
| | | Prediabetes | Diabetes | value |
| | 326 | 743 | | | Men; (%) | 176 (54.0%) | 445 (59.9%) | 0.069 | | Age (years) | 48 ± 9 | 55 ± 7 | 0.001 | | Body mass index (BMI; kg/m2) | 24 ± 3 | 25 ± 3 | 0.046 | | Fasting blood glucose (FBG; mg/dL) | 111.7 ± 7.2 | 151.4 ± 39.6 | <0.001 | | Hemoglobin A1c (HbA1c; %) | 5.6 ± 0.3 | 7.3 ± 1.4 | <0.001 | | Fasting insulin (pmol/L) | 61.8 ± 25.0 | 66.0 ± 31.9 | 0.041 | | Fasting C-peptide (nmol/L) | 0.8 ± 0.4 | 0.9 ± 0.5 | 0.001 | | High-sensitivity CRP (mg/L) | 0.13 ± 0.02 | 0.22 ± 0.02 | 0.008 | | Triglyceride (mmol/L) | 1.4 ± 0.0 | 1.8 ± 0.0 | <0.001 | | Total cholesterol (mmol/L) | 5.1 ± 0.1 | 4.9 ± 0.1 | 0.060 | | HDL cholesterol (mmol/L) | 1.33 ± 0.02 | 1.27 ± 0.01 | 0.002 | | LDL cholesterol (mmol/L) | 3.0 ± 0.1 | 2.9 ± 0.0 | 0.083 | | Duration of diabetes (years) | — | 5.7 ± 5.8 | | | Diabetic medication; (%) | — | 561 (75.5%) | | | Antidyslipidemia medication, (%) | 26 (7.9%) | 149 (20.1%) | 0.001 | | Smoking status, (%) | 41 (12.7%) | 164 (22.1%) | 0.001 | | Hypertension; (%) | 40 (12.3%) | 324 (43.6%) | <0.001 |
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CRP: C-reactive protein; HDL: high-density lipoprotein; LDL: low-density lipoprotein.
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