Genetic Variation in CYP17A1 Is Associated with Arterial Stiffness in Diabetic Subjects

Table 2

Clinical and hemodynamic parameters of prediabetic and diabetic subjects.

	Prediabetes			Diabetes
	Normotensive	Hypertensive	Normotensive	Hypertensive
				Without medication	With medication
𝑁	286	40	419	37	287
Men; 𝑛 (%)	152 (53%)	24 (60%)	247 (59%)	26 (70%)	172 (60%)
Age (years)	47.2 ± 8.7^a	53.6 ± 5.5^b	53.3 ± 7.6^b	52.6 ± 8.7^b	57.0 ± 5.8^c
Body mass index (BMI; kg/m^2)	24.3 ± 3.0^a	25.0 ± 2.8^ab	24.1 ± 3.2^a	25.6 ± 3.3^b	25.8 ± 3.2^b
Duration of diabetes (years)	—	—	5.2 ± 5.8^a	2.6 ± 4.4^b	6.9 ± 5.7^c
Systolic blood pressure (SBP; mmHg)	119.6 ± 13.5^a	127.7 ± 12.9^bc	123.1 ± 14.0^b	129.3 ± 14.2^c	126.7 ± 14.7^c
Diastolic blood pressure (DBP; mmHg)	74.4 ± 9.7^a	80.3 ± 11.0^bc	76.2 ± 9.3^d	80.7 ± 8.2^b	77.3 ± 9.1^cd
Central SBP (cSBP; mmHg)	121.4 ± 0.9^a	133.1 ± 1.6^b	127.9 ± 15.4^c	142.4 ± 18.6^d	135.0 ± 16.6^bd
Central DBP (cDBP; mmHg)	76.9 ± 0.6^a	83.7 ± 1.3^b	77.2 ± 10.6^a	82.9 ± 7.7^bc	79.6 ± 10.1^c
Pulse pressure (PP; mmHg)	44.5 ± 0.5^a	49.4 ± 1.0^b	50.7 ± 10.6^b	59.5 ± 13.5^c	55.4 ± 12.8^c
Augmentation index (AI; %)	74.5 ± 12.1^a	98.3 ± 9.3^b	123.5 ± 182.0^c	123.9 ± 261.7^c	137.7 ± 180.9^c
PWV, heart-carotid (hcPWV; m/s)	6.85 ± 0.10^a	7.95 ± 0.25^bc	7.73 ± 1.54^b	8.19 ± 1.92^bc	8.23 ± 1.89^c
PWV, carotid-brachial (cbPWV; m/s)	4.42 ± 0.04^a	4.75 ± 0.07^b	4.73 ± 0.57^b	4.90 ± 0.64^b	4.76 ± 0.53^b
PWV, heart-femoral (hfPWV; m/s)	8.15 ± 0.09^a	8.84 ± 0.14^b	9.53 ± 1.90^c	10.63 ± 2.04^d	10.06 ± 2.17^d

PWV: pulse wave velocity. Different letters within a variable are significantly different at P < 0.05.