Genetic Variation in CYP17A1 Is Associated with Arterial Stiffness in Diabetic Subjects

Table 4

Associations of SNP genotypes and hemodynamic parameters.

Set	Parameters	rs number	Nearby gene (s)	Statistical methods	P	Corrected P
	SBP	rs6749447	STK39	Linear regression	0.0100	0.5213
Prediabetes		rs2384550	TBX3	Linear regression	0.0341	1
	DBP	rs699	AGT	Linear regression	0.0021	0.1079
	SBP	rs17249754	ATP2B1	Linear regression	0.0480	1
	DBP	rs7926335	PLEKHA7	Linear regression	0.0297	1
		rs381815	PLEKHA7	Linear regression	0.0349	1
	cDBP	rs7926335	PLEKHA7	Linear regression	0.0072	0.3754
		rs381815	PLEKHA7	Linear regression	0.0096	0.4970
		rs1004467	CYP17A1	Median regression	0.0001	0.0060
Diabetes without antihypertensive medication	AI	rs7926335	PLEKHA7	Median regression	0.0316	1
		rs381815	PLEKHA7	Median regression	0.0428	1
		rs16998073	FGF5	Median regression	0.0105	0.5435
	hcPWV	rs10889553	LEPR	Linear regression	0.0472	1
		rs17097182	LEPR	Linear regression	0.0472	1
		rs4961	ADD1	Linear regression	0.0043	0.2216
	hfPWV	rs1937506	PCDH9	Linear regression	0.0032	0.1639
		rs1801058	GRK4	Linear regression	0.0095	0.4932
	DBP	rs7961152	BCAT1	Linear regression	0.0138	0.7169
	cSBP	rs2303934	SLC4A2	Linear regression	0.0408	1
		rs2681492	ATP2B1	Linear regression	0.0304	1
	cDBP	rs2681472	ATP2B1	Linear regression	0.0257	1
		rs2303934	SLC4A2	Linear regression	0.0249	1
		rs17249754	ATP2B1	Linear regression	0.0292	1
		rs995322	CSMD1	Linear regression	0.0355	1
	PP	rs10889553	LEPR	Linear regression	0.0242	1
		rs17097182	LEPR	Linear regression	0.0238	1
	AI	rs6495122	CPLX3	Median regression	0.0281	1
		rs10889553	LEPR	Median regression	0.0485	1
Diabetes with antihypertensive medication		rs5443	GNB3	Median regression	0.0485	1
	hcPWV	rs12946454	ACBD4	Median regression	0.0202	1
		rs1530440	C10orf107	Median regression	0.0198	1
		rs1799998	CYP11B2	Median regression	0.0014	0.0725
		rs394112	SLC8A1	Linear regression	0.0452	1
		rs10889553	LEPR	Linear regression	0.0260	1
	cbPWV	rs1378942	CSK	Linear regression	0.0210	1
		rs17097182	LEPR	Linear regression	0.0258	1
		rs17367504	MTHFR	Linear regression	0.0416	1
	hfPWV	rs2303934	SLC4A2	Linear regression	0.0049	0.2527
		rs1937506	PCDH9	Linear regression	0.0455	1

SBP: systolic blood pressure; DBP: diastolic blood pressure; cSBP: central systolic blood pressure; cDBP: central diastolic blood pressure; AI: augmentation index; PP: pulse pressure; hcPWV: heart-carotid pulse wave velocity; hfPWV: heart-femoral pulse wave velocity; cbPWV: carotid-brachial pulse wave velocity.