Short-Chain Fatty Acid Propionate Alleviates Akt2 Knockout-Induced Myocardial Contractile Dysfunction

Figure 2

Cardiomyocyte mechanical function in WT and Akt2 knockout (AKTKO) mice treated with or without propionate (0.3 g/kg, i.p.) for 7 days. (a) Resting cell length; (b) peak shortening (PS, normalized to resting cell length); (c) maximal velocity of shortening (+ dL/dt); (d) maximal velocity of relengthening (− dL/dt); (e) time-to-PS (TPS); (f) time-to-90% relengthening (TR₉₀). Mean ± SEM, 𝑛=103-104 cells per group, *P < 0.05 versus WT group, and ^#P < 0.05 versus AKTKO group.

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