Single Diabetic QTL Derived from OLETF Rat Is a Sufficient Agent for Severe Diabetic Phenotype in Combination with Leptin-Signaling Deficiency

Figure 1

Effects of oral glucose injection on plasma glucose of the congenic strains. Glucose tolerance in 15-week-old rats of the congenic strains F.Z-lepr (circles), F.Z/O-lepr, Nidd1/of (triangles), F.Z/O-lepr,   Nidd2/of (squares), OLETF rats (crosses), and F344 (filled squares). ^∗𝑃<0.05, ^∗∗𝑃<0.01, ^∗∗∗𝑃<0.001 versus F.Z-lepr.