Regulation of RAGE for Attenuating Progression of Diabetic Vascular Complications

Table 1

RAGE and its ligand axis in diabetic angiopathy using RAGE gene-manipulated animal models.

Animal models	Phenotypes	References
Diabetic nephropathy
RAGE transgenic mice	Nephropathy ↑	[48, 50]
(Type 1 diabetes)
+ AGE inhibitor	Nephropathy ↓
RAGE knockout mice	Nephropathy ↓	[51, 93]
(Type 1 diabetes)
+ LMWH treatment	Nephropathy ↓
RAGE knockout mice	Nephropathy ↓	[53]
(Type 1 diabetes, OVE26)
db/db mice + sRAGE	Nephropathy ↓	[52]
RAGE knockout mice	Nephropathy ↓
(STZ-diabetes)
Diabetic retinopathy
RAGE transgenic mice	Retinopathy ↑	[60]
(STZ-diabetes)
+ sRAGE treatment	Retinopathy ↓
RAGE transgenic mice	Retinopathy ↑	[80]
(Type 1 diabetes)
Diabetic neuropathy
RAGE knockout mice	Neuropathy ↓	[63]
(STZ diabetes)
+ sRAGE treatment	Neuropathy ↓
RAGE knockout mice	Neuropathy ↓	[64]
(STZ diabetes)