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Experimental Diabetes Research
Volume 2012, Article ID 960318, 7 pages
http://dx.doi.org/10.1155/2012/960318
Research Article

Common Variants of Homocysteine Metabolism Pathway Genes and Risk of Type 2 Diabetes and Related Traits in Indians

1Genomics and Molecular Medicine Unit, CSIR-Institute of Genomics and Integrative Biology, New Delhi 110 007, India
2Human Genetics Unit, Indian Statistical Institute, Kolkata 700 108, India
3Department of Endocrinology, All India Institute of Medical Sciences, New Delhi 110 029, India

Received 27 May 2011; Revised 26 July 2011; Accepted 1 August 2011

Academic Editor: Jun Ren

Copyright © 2012 Ganesh Chauhan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. L. L. Humphrey, R. Fu, K. Rogers, M. Freeman, and M. Helfand, “Homocysteine level and coronary heart disease incidence: a systematic review and meta-analysis,” Mayo Clinic Proceedings, vol. 83, no. 11, pp. 1203–1212, 2008. View at Publisher · View at Google Scholar · View at Scopus
  2. M. Soinio, J. Marniemi, M. Laakso, S. Lehto, and T. Rönnemaa, “Elevated plasma homocysteine level is an independent predictor of coronary heart disease events in patients with type 2 diabetes mellitus,” Annals of Internal Medicine, vol. 140, no. 2, pp. 94–100, 2004. View at Google Scholar · View at Scopus
  3. J. B. Meigs, P. F. Jacques, J. Selhub et al., “Fasting plasma homocysteine levels in the insulin resistance syndrome: the framingham offspring study,” Diabetes Care, vol. 24, no. 8, pp. 1403–1410, 2001. View at Google Scholar · View at Scopus
  4. L. Brazionis, K. Rowley, C. Itsiopoulos, C. A. Harper, and K. O'Dea, “Homocysteine and diabetic retinopathy,” Diabetes Care, vol. 31, no. 1, pp. 50–56, 2008. View at Publisher · View at Google Scholar · View at Scopus
  5. H. C. Looker, A. Fagot-Campagna, E. W. Gunter et al., “Homocysteine as a risk factor for nephropathy and retinopathy in Type 2 diabetes,” Diabetologia, vol. 46, no. 6, pp. 766–772, 2003. View at Publisher · View at Google Scholar · View at Scopus
  6. M. Buysschaert, A. S. Dramais, P. E. Wallemacq, and M. P. Hermans, “Hyperhomocysteinemia in type 2 diabetes: relationship to macroangiopathy, nephropathy, and insulin resistance,” Diabetes Care, vol. 23, no. 12, pp. 1816–1822, 2000. View at Google Scholar · View at Scopus
  7. P. F. Jacques, A. G. Bostom, P. W. F. Wilson, S. Rich, I. H. Rosenberg, and J. Selhub, “Determinants of plasma total homocysteine concentration in the framingham offspring cohort,” American Journal of Clinical Nutrition, vol. 73, no. 3, pp. 613–621, 2001. View at Google Scholar · View at Scopus
  8. R. Martos, M. Valle, R. Morales, R. Cañete, M. I. Gavilan, and V. Sánchez-Margalet, “Hyperhomocysteinemia correlates with insulin resistance and low-grade systemic inflammation in obese prepubertal children,” Metabolism, vol. 55, no. 1, pp. 72–77, 2006. View at Publisher · View at Google Scholar · View at Scopus
  9. G. Ntaios, C. Savopoulos, S. Chatzopoulos, D. Mikhailidis, and A. Hatzitolios, “Iatrogenic hyperhomocysteinemia in patients with metabolic syndrome: a systematic review and metaanalysis,” Atherosclerosis, vol. 214, no. 1, pp. 11–19, 2011. View at Publisher · View at Google Scholar · View at Scopus
  10. N. Weiss, S. J. Heydrick, O. Postea, C. Keller, J. F. Keaney Jr., and J. Loscalzo, “Influence of hyperhomocysteinemia on the cellular redox state—impact on homocysteine-induced endothelial dysfunction,” Clinical Chemistry and Laboratory Medicine, vol. 41, no. 11, pp. 1455–1461, 2003. View at Publisher · View at Google Scholar · View at Scopus
  11. M. A. Hofmann, E. Lalla, Y. Lu et al., “Hyperhomocysteinemia enhances vascular inflammation and accelerates atherosclerosis in a murine model,” Journal of Clinical Investigation, vol. 107, no. 6, pp. 675–683, 2001. View at Google Scholar · View at Scopus
  12. J. S. Stamler, J. A. Osborne, O. Jaraki et al., “Adverse vascular effects of homocysteine are modulated by endothelium- derived relaxing factor and related oxides of nitrogen,” Journal of Clinical Investigation, vol. 91, no. 1, pp. 308–318, 1993. View at Google Scholar · View at Scopus
  13. Y. Song, N. R. Cook, C. M. Albert, M. Van Denburgh, and J. E. Manson, “Effect of homocysteine-lowering treatment with folic acid and B vitamins on risk of type 2 diabetes in women: a randomized, controlled trial,” Diabetes, vol. 58, no. 8, pp. 1921–1928, 2009. View at Publisher · View at Google Scholar · View at Scopus
  14. S. Wild, G. Roglic, A. Green, R. Sicree, and H. King, “Global prevalence of diabetes: estimates for the year 2000 and projections for 2030,” Diabetes Care, vol. 27, no. 10, pp. 1047–1053, 2004. View at Publisher · View at Google Scholar · View at Scopus
  15. R. Gupta, P. C. Deedwania, A. Gupta, S. Rastogi, R. B. Panwar, and K. Kothari, “Prevalence of metabolic syndrome in an Indian urban population,” International Journal of Cardiology, vol. 97, no. 2, pp. 257–261, 2004. View at Publisher · View at Google Scholar · View at Scopus
  16. N. K. Vikram, R. M. Pandev, R. Sharma, and A. Misra, “Hyperhomocysteinemia in healthy Asian Indians,” American Journal of Hematology, vol. 72, no. 2, pp. 151–152, 2003. View at Publisher · View at Google Scholar · View at Scopus
  17. S. Mehri, N. Koubaa, A. Nakbi et al., “Relationship between genetic polymorphisms of angiotensin-converting enzyme and methylenetetrahydrofolate reductase as risk factors for type 2 diabetes in Tunisian patients,” Clinical Biochemistry, vol. 43, no. 3, pp. 259–266, 2010. View at Publisher · View at Google Scholar · View at Scopus
  18. F. I. V. Errera, M. E. R. Silva, E. Yeh et al., “Effect of polymorphisms of the MTHFR and APOE genes on susceptibility to diabetes and severity of diabetic retinopathy in Brazilian patients,” Brazilian Journal of Medical and Biological Research, vol. 39, no. 7, pp. 883–888, 2006. View at Publisher · View at Google Scholar · View at Scopus
  19. J. T. Bazzaz, M. Shojapoor, H. Nazem et al., “Methylenetetrahydrofolate reductase gene polymorphism in diabetes and obesity,” Molecular Biology Reports, vol. 37, no. 1, pp. 105–109, 2010. View at Publisher · View at Google Scholar · View at Scopus
  20. P. Frosst, H. J. Blom, R. Milos et al., “A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase,” Nature Genetics, vol. 10, no. 1, pp. 111–113, 1995. View at Google Scholar · View at Scopus
  21. P. Beneš, K. Kaňková, J. Mužík et al., “Methylenetetrahydrofolate reductase polymorphism, type II diabetes mellitus, coronary artery disease, and essential hypertension in the Czech population,” Molecular Genetics and Metabolism, vol. 73, no. 2, pp. 188–195, 2001. View at Publisher · View at Google Scholar · View at Scopus
  22. A. R. Chen, H. G. Zhang, Z. P. Wang et al., “C-reactive protein, vitamin B12 and C677T polymorphism of N-5,10-methylenetetrahydrofolate reductase gene are related to insulin resistance and risk factors for metabolic syndrome in Chinese population,” Clinical and Investigative Medicine, vol. 33, no. 5, pp. E290–E297, 2010. View at Google Scholar · View at Scopus
  23. R. Nemr, R. A. Salman, L. H. Jawad, E. A. Juma, S. H. Keleshian, and W. Y. Almawi, “Differential contribution of MTHFR C677T variant to the risk of diabetic nephropathy in Lebanese and Bahraini Arabs,” Clinical Chemistry and Laboratory Medicine, vol. 48, no. 8, pp. 1091–1094, 2010. View at Publisher · View at Google Scholar · View at Scopus
  24. M. Rahimi, A. Hasanvand, Z. Rahimi et al., “Synergistic effects of the MTHFR C677T and A1298C polymorphisms on the increased risk of micro- and macro-albuminuria and progression of diabetic nephropathy among Iranians with type 2 diabetes mellitus,” Clinical Biochemistry, vol. 43, no. 16-17, pp. 1333–1339, 2010. View at Publisher · View at Google Scholar · View at Scopus
  25. G. T. Russo, A. Di Benedetto, D. Magazzù et al., “Mild hyperhomocysteinemia, C677T polymorphism on methylenetetrahydrofolate reductase gene and the risk of macroangiopathy in type 2 diabetes: a prospective study,” Acta Diabetologica, vol. 48, no. 2, pp. 95–101, 2011. View at Publisher · View at Google Scholar
  26. J. Z. Sun, Y. Xu, H. Lu, and Y. Zhu, “Polymorphism of the methylenetetrahydrofolate reductase gene association with homocysteine and ischemic stroke in type 2 diabetes,” Neurology India, vol. 57, no. 5, pp. 589–593, 2009. View at Publisher · View at Google Scholar · View at Scopus
  27. I. Terruzzi, P. Senesi, I. Fermo, G. Lattuada, and L. Luzi, “Are genetic variants of the methyl group metabolism enzymes risk factors predisposing to obesity?” Journal of Endocrinological Investigation, vol. 30, no. 9, pp. 747–753, 2007. View at Google Scholar · View at Scopus
  28. J. Kumar, G. Garg, A. Kumar et al., “Single nucleotide polymorphisms in homocysteine metabolism pathway genes: association of CHDH A119C and MTHFR C677T with hyperhomocysteinemia,” Circulation, vol. 2, no. 6, pp. 599–606, 2009. View at Publisher · View at Google Scholar
  29. U. K. Misra, J. Kalita, A. K. Srivastava, and S. Agarwal, “MTHFR gene polymorphism and its relationship with plasma homocysteine and folate in a North Indian population,” Biochemical Genetics, vol. 48, no. 3-4, pp. 229–235, 2010. View at Publisher · View at Google Scholar · View at Scopus
  30. R. Tabassum, S. Chavali, O. P. Dwivedi, N. Tandon, and D. Bharadwaj, “Genetic variants of FOXA2: risk of type 2 diabetes and effect on metabolic traits in North Indians,” Journal of Human Genetics, vol. 53, no. 11-12, pp. 957–965, 2008. View at Publisher · View at Google Scholar · View at Scopus
  31. J. R. Gavin, K. G. M. M. Alberti, M. B. Davidson et al., “Report of the expert committee on the diagnosis and classification of diabetes mellitus,” Diabetes Care, vol. 26, no. 1, pp. S5–S20, 2003. View at Google Scholar · View at Scopus
  32. C. Barba, T. Cavalli-Sforza, J. Cutter et al., “Appropriate body-mass index for Asian populations and its implications for policy and intervention strategies,” The Lancet, vol. 363, no. 9403, pp. 157–163, 2004. View at Publisher · View at Google Scholar
  33. D. R. Matthews, J. P. Hosker, A. S. Rudenski, B. A. Naylor, D. F. Treacher, and R. C. Turner, “Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man,” Diabetologia, vol. 28, no. 7, pp. 412–419, 1985. View at Google Scholar
  34. J. C. Levy, D. R. Matthews, and M. P. Hermans, “Correct homeostasis model assessment (HOMA) evaluation uses the computer program,” Diabetes Care, vol. 21, no. 12, pp. 2191–2192, 1998. View at Google Scholar · View at Scopus
  35. K. S. Brown, L. A. J. Kluijtmans, I. S. Young et al., “Genetic evidence that nitric oxide modulates homocysteine: the NOS3 894TT genotype is a risk factor for hyperhomocystenemia,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 23, no. 6, pp. 1014–1020, 2003. View at Publisher · View at Google Scholar · View at Scopus
  36. G. Chauhan, C. J. Spurgeon, R. Tabassum et al., “Impact of common variants of PPARG, KCNJ11, TCF7L2, SLC30A8, HHEX, CDKN2A, IGF2BP2, and CDKAL1 on the risk of type 2 diabetes in 5,164 Indians,” Diabetes, vol. 59, no. 8, pp. 2068–2074, 2010. View at Publisher · View at Google Scholar · View at Scopus
  37. R. Tabassum, A. Mahajan, G. Chauhan et al., “Evaluation of DOK5 as a susceptibility gene for type 2 diabetes and obesity in North Indian population,” BMC Medical Genetics, vol. 11, article 35, 2010. View at Publisher · View at Google Scholar · View at Scopus
  38. P. Yi, S. Melnyk, M. Pogribna, I. P. Pogribny, R. J. Hine, and S. J. James, “Increase in plasma homocysteine associated with parallel increases in plasma S-adenosylhomocysteine and lymphocyte DNA hypomethylation,” Journal of Biological Chemistry, vol. 275, no. 38, pp. 29318–29323, 2000. View at Publisher · View at Google Scholar · View at Scopus
  39. S. Bleich, B. Lenz, M. Ziegenbein et al., “Epigenetic DNA hypermethylation of the HERP gene promoter induces down-regulation of its mRNA expression in patients with alcohol dependence,” Alcoholism Research, vol. 30, no. 4, pp. 587–591, 2006. View at Publisher · View at Google Scholar · View at Scopus
  40. R. Thaler, M. Agsten, S. Spitzer et al., “Homocysteine suppresses the expression of the collagen cross-linker lysyl oxidase involving IL-6, Fli1, and epigenetic DNA methylation,” Journal of Biological Chemistry, vol. 286, no. 7, pp. 5578–5588, 2011. View at Publisher · View at Google Scholar
  41. G. Paré, D. I. Chasman, A. N. Parker et al., “Novel associations of CPS1, MUT, NOX4, and DPEP1 with plasma Homocysteine in a healthy population a genome-wide evaluation of 13 974 participants in the women's genome health study,” Circulation, vol. 2, no. 2, pp. 142–150, 2009. View at Publisher · View at Google Scholar · View at Scopus
  42. L. Zhang, R. X. Yin, W. Y. Liu et al., “Association of methylenetetrahydrofolate reductase C677T polymorphism and serum lipid levels in the Guangxi Bai Ku Yao and Han populations,” Lipids in Health and Disease, vol. 9, article 123, 2010. View at Publisher · View at Google Scholar · View at Scopus
  43. R. Kawamoto, K. Kohara, Y. Tabara et al., “An association of 5,10-methylenetetrahydrofolate reductase (MTHFR) gene polymorphism and common carotid atherosclerosis,” Journal of Human Genetics, vol. 46, no. 9, pp. 506–510, 2001. View at Publisher · View at Google Scholar · View at Scopus
  44. T. Helfenstein, F. A. H. Fonseca, W. G. M. Relvas et al., “Prevalence of myocardial infarction is related to hyperhomocysteinemia but not influenced by C677T methylenetetrahydrofolate reductase and A2756G methionine synthase polymorphisms in diabetic and non-diabetic subjects,” Clinica Chimica Acta, vol. 355, no. 1-2, pp. 165–172, 2005. View at Publisher · View at Google Scholar · View at Scopus
  45. A. Mahajan, R. Tabassum, S. Chavali et al., “Obesity-dependent association of TNF-LTA locus with type 2 diabetes in North Indians,” Journal of Molecular Medicine, vol. 88, no. 5, pp. 515–522, 2010. View at Publisher · View at Google Scholar · View at Scopus
  46. R. Tabassum, S. Chavali, A. Mahajan et al., “Association analysis of TNFRSF1B polymorphisms with type 2 diabetes and its related traits in North India,” Genomic Medicine, vol. 2, no. 3-4, pp. 93–100, 2008. View at Publisher · View at Google Scholar · View at Scopus
  47. S. K. Brahmachari, P. P. Majumder, M. Mukerji et al., “Genetic landscape of the people of India: a canvas for disease gene exploration,” Journal of Genetics, vol. 87, no. 1, pp. 3–20, 2008. View at Publisher · View at Google Scholar
  48. J. Kumar, S. K. Das, P. Sharma, G. Karthikeyan, L. Ramakrishnan, and S. Sengupta, “Homocysteine levels are associated with MTHFR A1298C polymorphism in Indian population,” Journal of Human Genetics, vol. 50, no. 12, pp. 655–663, 2005. View at Publisher · View at Google Scholar · View at Scopus