The Role of Adrenomedullin in the Renal NADPH Oxidase and (Pro)renin in Diabetic Mice

Table 1

Physiological data.

	Wild-control	Wild-DM	AMKO-control	AMKO-DM
Body weight (g)	22.0 ± 0.4	16.9 ± 1.1^**++	24.5 ± 0.6	18.9 ± 0.9^*++
Blood glucose (mg/dL)	109 ± 3	361 ± 45^**++	161 ± 16	410 ± 27^**++
Urinary protein (mg/mg Cr)	ND	29 ± 3	ND	44 ± 4^#
Plasma angiotensin II (pg/mL)	33.3 ± 11.0	19.0 ± 3.9	34.5 ± 1.5	59.3 ± 19.0^#
Renal angiotensin II (pg/g kidney)	615 ± 102	685 ± 71^++	269 ± 32*	458 ± 81^#

^∗𝑃<0.05, **𝑃<0.001 versus Wild control, ⁺𝑃<0.05, ⁺⁺𝑃<0.001 versus AMKO control, ^#𝑃<0.05 versus Wild-DM. 𝑁=4 in each group.