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Journal of Diabetes Research
Volume 2013 (2013), Article ID 138969, 6 pages
Research Article

Levels of Inflammatory Cytokines in Type 2 Diabetes Patients with Different Urinary Albumin Excretion Rates and Their Correlation with Clinical Variables

1Department of Geriatrics, The First Affiliated Hospital, China Medical University, Shenyang 110001, China
2Department of Endocrinology, Fengtian Hospital of Shenyang Medical College, Shenyang 110000, China
3Department of Endocrinology, The Fourth People’s Hospital of Shenyang, Shenyang 110031, China
4Department of Endocrinology, The First Affiliated Hospital, China Medical University, Shenyang 110001, China

Received 4 September 2013; Accepted 29 October 2013

Academic Editor: Tomohito Gohda

Copyright © 2013 Fen-qin Chen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Although the pathogenetic mechanism of DN has not been elucidated, an inflammatory mechanism has been suggested as a potential contributor. This study was designed to explore the relationship between low-grade inflammation and renal microangiopathy in T2DM. A total of 261 diabetic subjects were divided into three groups according to UAE: a normal albuminuria group, a microalbuminuria group, and a macroalbuminuria group. A control group was also chosen. Levels of hs-CRP, TNF- , uMCP-1, SAA, SCr, BUN, serum lipid, blood pressure, and HbA1c were measured in all subjects. Compared with the normal controls, levels of hs-CRP, TNF- , uMCP-1, and SAA in T2DM patients were significantly higher. They were also elevated in the normal albuminuria group, . Compared with the normal albuminuria group, levels of these inflammatory cytokines were significantly higher in the microalbuminuria and macroalbuminuria group, . The macroalbuminuria group also showed higher levels than the microalbuminuria group, . Also they were positively correlated with UAE, SBP, DBP, LDL-C, and TC. We noted no significance correlated with course, TG, or HDL-C. Only TNF- ; was positively correlated with HbA1c. This study revealed the importance of these inflammatory cytokines in DN pathogenesis. Further studies are needed to fully establish the potential of these cytokines as additional biomarkers for the development of DN.