Comparison of Two New Mouse Models of Polygenic Type 2 Diabetes at the Jackson Laboratory, NONcNZO10Lt/J and TALLYHO/JngJ

Table 1

Comparison of selected serum analytes in the male cohorts shown in the figures. Data show mean ± SEM for 8–10 males at 20 weeks of age. Lean age-matched BKS males are shown for comparison. Groups were maintained on 6% fat chow except for NcZ10 males that were fed 11% fat chow. Hemoglobin A1c (HbA1c) values are shown to document chronic hyperglycemia in the 3 diabetic stocks.

Strain	Glucose; mg/dL	HbA1c; % NGSP units	Triglyceride; mg/dL	Total cholesterol; mg/dL	HDL cholesterol; mg/dL	Nonesterified fatty acids; mEq/L	ALT^f; (IU/L)
NcZ10	475±30	10.4 ± 0.2	255 ± 12^e	128 ± 4^e	97 ± 3	1.90 ± 0.08^e	44.2 ± 1.1
TH	520±36	9.0 ± 0.5	491 ± 57	151 ± 3	106 ± 3	2.47 ± 0.09	44.6 ± 4.1
BKS-db/db	444±48	12.8 ± 0.8^d	141 ± 12^b	163 ± 6	127 ± 5^d	2.82 ± 0.17	125.1 ± 9.8^f
BKS-m+/m+^a	167±14^c	5.7 ± 0.2^c	131 ± 7^b	98 ± 6^c	71 ± 2^c	1.92 ± 0.08	39.2 ± 5.3

am+/m+ from the cross with the db gene in repulsion with the misty (m) gene.
^bdb/db and lean control significantly lower (𝑃≤0.05) than TH and NcZ10.
^cLean control significantly lower (𝑃≤0.05) than all 3 diabetic stocks.
^ddb/db significantly higher (𝑃≤0.05) than TH and NcZ10.
^eNcZ10 significantly lower (𝑃≤0.05) than TH and db/db.
^fAlanine aminotransferase; db/db significantly higher (𝑃≤0.05) than control, TH, and NcZ10.