MicroRNA in Diabetic Nephropathy: Renin Angiotensin, AGE/RAGE, and Oxidative Stress Pathway

Table 1

Relevant miRNA in RAAS.

miRNAs	Tissue/organ/cell line	Source	Target	Functions	Reference
miR-181a	Kidney	Hypertensive patients	REN, AIFM1	Hypertension	[33]
miR-663			REN, APOE
miR-155	Blood	CKD patients	AT1R	Hypertension, cardiovascular disease	[34]
miR-29b, -129-3p, -132, -132-5P and -212	HEK293N cells, cardiac fibroblasts	Human, Rat		Associated with cardiovascular disease	[35]
miR-132/212	Heart, aortic wall, and kidneys	Rat		Associated with blood pressure control	[36]
	Artery	ARB-treated patients

AIFM1: apoptosis-inducing factor, mitochondrion-associated, 1; APOE: apolipoprotein E; AT1R: angiotensin II receptor, type 1; CKD: chronic kidney disease; HEK: human embryonic kidney cells; RAAS: renin-angiotensin-aldosterone system; REN: renin.