MicroRNA in Diabetic Nephropathy: Renin Angiotensin, AGE/RAGE, and Oxidative Stress Pathway

Table 2

Relevant miRNA in AGE/RAGE.

miRNAs	Tissue/organ/cell line	Source	Target	Functions	Reference
miR-30 family	Podocyte	Mice	AGER, Vim, HSP20, Ier3	Podocyte homeostasis and podocytopathies	[40]
miR-16	THP-1 monocytic cells	Human	COX-2	Regulate inflammation	[41]
miR-214	THP-1 monocytic cells	Human	PTEN	Monocyte survival	[42]
miR-221/222	VSMCs	Rat	p27^Kip1 and p57^Kip2	Cell proliferation	[44]
miR-221/222	Endothelial cells	Human	p27^Kip1 and p57^Kip2	Cell proliferation	[45]
miR-21 and miR-221	MES 13 mesangial cells	Mice	Timp3	DN progression	[46]
miR-21	Kidney	Human
miR-221/miR-222	HUVECs	Human	c-Kit	Reduced EC migration	[48]

AGE: advanced glycation end-product; AGER: advanced glycosylation end-product-specific receptor; c-kit: V-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog; COX: Cyclooxygenase; DN: diabetic nephropathy; EC: endothelial cells; HSP: Heat shock protein; HUVECs: human umbilical vein endothelial cells; Ier3: immediate early response 3; p27^Kip1: Cyclin-Dependent Kinase Inhibitor 1B; p57^Kip2: Cyclin-Dependent Kinase Inhibitor 1C; PTEN: phosphatase and tensin homolog; RAGE: Receptor for AGE; Timp: metallopeptidase inhibitor; Vim: Vimentin; VSMCs: vascular smooth muscle cells.