Effects of Long-Term Treatment with Ranirestat, a Potent Aldose Reductase Inhibitor, on Diabetic Cataract and Neuropathy in Spontaneously Diabetic Torii Rats
The sorbitol levels in the sciatic nerves at 40 weeks. The sorbitol level in the sciatic nerves in the untreated SDT rats is significantly higher that of the SD rats. , Student’s -test. The sorbitol levels in the sciatic nerves treated with all doses of ranirestat (10.0 and 1.0 mg/kg/day) are lower than in the untreated SDT rats. and , Dunnett type joint-ranking test. Epalrestat does not affect the reduction in the sorbitol level. NDM: non-diabetes mellitus; DM: diabetes mellitus; rani: ranirestat; epal: epalrestat.