Effects of Long-Term Treatment with Ranirestat, a Potent Aldose Reductase Inhibitor, on Diabetic Cataract and Neuropathy in Spontaneously Diabetic Torii Rats
Pathology (hematoxylin, original magnification 4x) at 40 weeks. In an untreated eye (left), the lens has a sclerotic nucleus floating in liquefied cortex and vacuolation and disintegration of cortex fibers. In the epalrestat-treated eye (middle), the findings are virtually the same as in the untreated eye. In the ranirestat-treated eyes (right), the eye has an almost normal lens and retina.