Effects of Long-Term Treatment with Ranirestat, a Potent Aldose Reductase Inhibitor, on Diabetic Cataract and Neuropathy in Spontaneously Diabetic Torii Rats
The total cataract scores at 40 weeks. The total cataract score of the untreated SDT rats at 40 weeks is significantly higher than that of the SD rats. , Wilcoxon rank sum test. The total cataract score of the SDT rats treated with ranirestat at 40 weeks is significantly lower than that of the untreated SDT rats. , Wilcoxon rank sum test. There is no significant difference in the total cataract score between the untreated SDT rats and the SDT rats treated with epalrestat. NDM: non-diabetes mellitus; DM: diabetes mellitus; rani: ranirestat; epa: epalrestat.