Research Article

Protective Effects of Resveratrol on TNF- -Induced Endothelial Cytotoxicity in Baboon Femoral Arterial Endothelial Cells

Figure 4

Resveratrol inhibited CAM expression induced by TNF- (10 ng/mL). TNF- significantly stimulated ICAM (CD54) and VCAM (CD106) expression after 4 H (a) and 24 h (b) treatment and significantly increased E-selectin (CD62e) expression after 4 h. Resveratrol (RSV) (10, 50  M) inhibited expression of ICAM and VCAM in activated BAECs stimulated with TNF- (10 ng/mL) during 24 h of cotreatment (b). Resveratrol (10, 50  M) administered pretreatment (c) also significantly inhibited the expression of ICAM and VCAM activated by TNF- , and significantly attenuated sustained ICAM and VCAM expression after TNF stimulation by posttreatment (d). Data are mean SEM from three independent experiments each performed in triplicate. * ; and ** versus control and & ; and && versus TNF- alone.