Protective Effects of Resveratrol on TNF-𝛼-Induced Endothelial Cytotoxicity in Baboon Femoral Arterial Endothelial Cells

Figure 4

Resveratrol inhibited CAM expression induced by TNF-𝛼 (10 ng/mL). TNF-𝛼 significantly stimulated ICAM (CD54) and VCAM (CD106) expression after 4 H (a) and 24 h (b) treatment and significantly increased E-selectin (CD62e) expression after 4 h. Resveratrol (RSV) (10, 50 𝜇M) inhibited expression of ICAM and VCAM in activated BAECs stimulated with TNF-𝛼 (10 ng/mL) during 24 h of cotreatment (b). Resveratrol (10, 50 𝜇M) administered pretreatment (c) also significantly inhibited the expression of ICAM and VCAM activated by TNF-𝛼, and significantly attenuated sustained ICAM and VCAM expression after TNF stimulation by posttreatment (d). Data are mean ± SEM from three independent experiments each performed in triplicate. *𝑃<0.05; and **𝑃<0.01 versus control and ^&𝑃<0.05; and ^&&𝑃<0.01 versus TNF-𝛼 alone.

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