Protective Effects of Resveratrol on TNF--Induced Endothelial Cytotoxicity in Baboon Femoral Arterial Endothelial Cells
Resveratrol inhibited CAM expression induced by TNF- (10 ng/mL). TNF- significantly stimulated ICAM (CD54) and VCAM (CD106) expression after 4 H (a) and 24 h (b) treatment and significantly increased E-selectin (CD62e) expression after 4 h. Resveratrol (RSV) (10, 50 M) inhibited expression of ICAM and VCAM in activated BAECs stimulated with TNF- (10 ng/mL) during 24 h of cotreatment (b). Resveratrol (10, 50 M) administered pretreatment (c) also significantly inhibited the expression of ICAM and VCAM activated by TNF-, and significantly attenuated sustained ICAM and VCAM expression after TNF stimulation by posttreatment (d). Data are mean SEM from three independent experiments each performed in triplicate. *; and ** versus control and &; and && versus TNF- alone.