The Role of Autophagy in the Pathogenesis of Diabetic Nephropathy

Figure 3

Autophagy in podocytes under diabetic conditions. Podocytes show high rates of autophagy even under nonstress conditions (upper panel). Autophagy activity is altered in podocytes under streptozotocin-induced type 1 diabetic conditions (lower panel). These results suggest that hyperglycemia alters autophagic activity, which may contribute to diabetes-related podocyte injury.