Table 1: Functional classification of altered proteins related to cardiac lipid metabolism, mitochondrial function, and cardiomyopathy.

Accession no.SymbolProtein nameMolecular weight (Da)PIiTRAQ ratio (DM/C)iTRAQ ratio (DMT/DM)

Cardiac lipid metabolism

IPI00785217LDLrLow-density lipoprotein receptor94947.384.820.223.05
IPI00943405MttpMicrosomal triglyceride transfer protein large subunit100750.947.510.41.83
IPI00655029Sorbs1Sorbin and SH3 domain-containing protein 1103977.895.650.461.83
IPI00320188NamptNicotinamide phosphoribosyltransferase55446.826.690.531.78
IPI00133956Gpihbp1Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 124566.224.815.710.19
IPI00124411PtplbProtein-tyrosine phosphatase-like member B28402.439.590.233.95
IPI00316479Ptpn11Tyrosine-protein phosphatase nonreceptor type 1168034.756.870.162.95

Mitochondrial components and function

IPI00882331LiasLipoyl synthase, mitochondrial32173.88.482.630.49
IPI00128345Ndufs6NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial13019.788.860.591.55
IPI00114840EndogEndonuclease G, mitochondrial32190.749.560.391.78
IPI00336348Atpaf2ATP synthase mitochondrial F1 complex assembly factor 234287.296.351.680.65
IPI00276157Aifm2Apoptosis-inducing factor 241355.638.162.580.45
IPI00929796Prkaa25′-AMP-activated protein kinase catalytic subunit alpha-262022.377.940.431.81

Cardiomyopathy

IPI00896736ApcAdenomatosis polyposis coli310880.67.442.390.45
IPI00315550Glrx3Glutaredoxin-337778.425.420.351.61
IPI00130102DesDesmin53497.995.210.31.7
IPI00116668IlkIntegrin-linked protein kinase51373.158.30.183.15
IPI00756257TtnTitin3906489.355.910.341.69
IPI00555015Myl2Myosin regulatory light chain 2, ventricular/cardiac muscle isoform18864.354.860.381.73
IPI00117846Dapk3Death-associated protein kinase 351421.98.910.332.45
IPI00828253DmdDystrophin425831.775.660.461.88
IPI00759948GsnGelsolin80762.655.520.412.33
IPI00222188Col1a2Collagen alpha-2(I) chain129556.979.270.172.05
IPI00620256LmnaIsoform A of Lamin-A/C74237.826.540.182.05
IPI00874362Lama2Laminin subunit alpha-2342781.065.780.321.51
IPI00119618CanxCalnexin67278.14.51.770.64
IPI00626655Myom1Myomesin-1185464.525.830.481.54
IPI00420996Cacnb2Voltage-dependent L-type calcium channel subunit beta-264714.539.170.591.69