The Effect of Simvastatin on Glucose Homeostasis in Streptozotocin Induced Type 2 Diabetic Rats

Table 2

Effect of intervention and treatment with simvastatin on fasting plasma glucose, serum total cholesterol, HDL-C, and triglycerides.

Groups	FPG; (mmol/L)	Total cholesterol; (mmol/L)	HDL-C; (mmol/L)	Triglycerides; (mmol/L)
Normal control
Baseline	4.5±0.8	2.0±0.2	0.85±0.02	1.3±0.1
After 4 weeks	4.6±0.6	2.1±0.1	0.87±0.01	1.2±0.2
After 12 weeks	4.4±0.3	2.2±0.3	0.92±0.03	1.1±0.2
Diabetic
Baseline	4.8±0.6	1.9±0.1	0.75±0.01	1.2±0.1
After 4 weeks	12.4±1.2^∗	3.7±0.8^∗	0.59±0.02^∗	2.6±0.3^∗
After 12 weeks	13.2±0.9^∗	4.0±0.5^∗	0.35±0.01^∗	3.4±0.2^∗
Simvastatin intervention
Baseline	4.6±0.1	2.1±0.2	0.83±0.02	1.4±0.1
After 4 weeks	17.5±0.9^*#	2.2±0.3^#	1.34±0.04^*#	1.2±0.3^∗
After 12 weeks	15.1±0.2^*#	2.0±0.1^#	1.56±0.02^*#	1.3±0.2^∗
Simvastatin treatment
Baseline	4.2±0.5	2.0±0.1	0.87±0.03	1.3±0.1
After 4 weeks	13.4±1.5^∗	3.2±0.1^*#	0.62±0.02^#	2.2±0.2^#
After 12 weeks	16.2±1.0^*#	2.1±0.3^*#	1.49±0.05^#	1.5±0.3^#

Data are the mean ± SD for ten animals in each group.
^∗𝑃<0.05 compared with the control group.
^#𝑃<0.05 compared with the untreated diabetic group.