Evaluation of the Association of Plasma Pentraxin 3 Levels with Type 2 Diabetes and Diabetic Nephropathy in a Malay Population
Table 1
Clinical and laboratory characteristics of Malay subjects with normal glucose tolerance, and type 2 diabetes patients with and without diabetic nephropathy.
Gender
Male
Female
Group ()
NGT (50)
T2DM − DN (40)
T2DM + DN (59)
valuesa/b
NGT (53)
T2DM − DN (51)
T2DM + DN (43)
valuesa/b
Age (years)
58 (56–60)
55 (53–58)
55 (52–58)
56 (54–59)
53 (50–56)
56 (53–59)
Diabetic duration (years)
—
14 (12–17)
14 (12–17)
—
12 (9–15)
12 (9–15)
BMI (kg/m2)
24.9 (23.6–26.2)
27.7 (26.4–29.1)
27.6 (26.0–29.1)
0.010/NS
27.2 (25.9–28.5)
29.1 (27.2–30.7)
27.2 (25.1–29.4)
SBP (mm Hg)
138 (132–144)
137 (129–144)
159 (147–170)
NS/0.001
137 (132–143)
144 (137–150)
149 (137–160)
DBP (mm Hg)
83 (79–85)
82 (79–85)
83 (79–88)
84 (80–87)
87 (83–91)
79 (73–85)
NS/0.047
FPG (mmol/L)
5.6 (5.0–6.1)
7.3 (5.3–9.4)
5.0 (4.74–5.6)
7.7 (5.6–9.9)
HbA1c (mmol/mol)
31 (29–33)
43 (33–52)
31 (21–41)
31 (30–33)
38 (30–44)
37 (26–46)
eGFR (mL/min/1.73 m2)
102 (88–117)
93 (81–105)
50 (42–58)
NS/<0.001
103 (92–113)
89 (79–98)
50 (36–64)
NS/<0.001
Creatinine (µmol/L)*
75.9 (69.2–83.2)
81.3 (67.6–93.3)
158.5 (134.9–195.0)
NS/<0.001
57.5 (53.7–63.1)
63.1 (60.3–75.9)
141.3 (112.2–117.8)
NS/<0.001
ACR (mg/mmol)*
0.89 (0.66–1.13)
1.03 (0.63–1.44)
179.0 (133.8–224.3)
0.001/<0.001
0.79 (0.64–0.95)
2.01 (0.25–3.76)
304.3 (149.4–459.3)
0.001/<0.001
Data are expressed as mean (95% CI) for normally distributed variables and as geometric means (95% CI) for nonnormally distributed variables*; NGT: normal glucose tolerance; T2DM: type 2 diabetes; BMI: body mass index; SBP and DBP: systolic and diastolic blood pressures; FPG: Fasting plasma glucose; HbA1c: glycosylated hemoglobin; eGFR: estimated glomerular filtration rate; ACR: albumin creatinine ratio; PTX3: pentraxin 3; values were from tests of NGT versus T2DM − DNa and T2DM − DN versus T2DM + DNb.
