Exacerbation of Glycoprotein VI-Dependent Platelet Responses in a Rhesus Monkey Model of Type 1 Diabetes

Table 1

Comparison of monkey parameters.

	Healthy	Well-controlled diabetes	Poorly-controlled diabetes
𝑛	6	6	6
Age (years)^†	5.50±0.96 (4–9)	4.17±0.17 (4–5)	5.67±0.21 (5–6)
Recent weight (kg) (July-Aug. 2011)	7.25±2.06	5.70±0.54 *	8.47±2.09
Gender	4 M, 2 F	2 M, 4 F	6 M
Monthly blood glucose level (mM)^†; (July-Aug. 2011)	4.7 ± 0. 15 (4.2–5.2)	7.87±0.53 * (2.6–18.20)	16.17±1.65 ***  (8.0–31.2)
Platelet count in whole blood^†	213.5±31.5 (139–330)	192.8±17.5 (137–241); 𝑛=5	193.4±15.3 (150–230); 𝑛=5
MPV^†	7.78±0.86 (7.3–9.31); 𝑛=5	7.98±1.67 (7.07–10.7); 𝑛=5	7.01±0.54 (6.56–7.95); 𝑛=5
Basal ROS (X-mean)	0.82±0.05	0.80±0.06	0.85±0.05
Immature platelet fraction; (TO staining; X-mean)	30.8±3.6	29.8±3.7	27.4±3.9

†Mean ± standard error (range).
* 𝑃<0.05; ***𝑃<0.001 compared with control.