Angiotensin-Converting Enzyme 2 Deficiency Aggravates Glucose Intolerance via Impairment of Islet Microvascular Density in Mice with High-Fat Diet
Table 1
Body weight, blood glucose, blood insulin, and islet function (mean ± SD).
WT
WH
KO
KH
Body weight (g) (beginning)
22.60 ± 0.65
22.73 ± 0.55
22.48 ± 0.33
22.56 ± 0.33
Body weight (g) (ending)
29.05 ± 0.83
34.24 ± 1.45*
29.21 ± 0.69
34.41 ± 0.69*#
Fasting blood glucose (mmol/L)
8.18 ± 0.72
8.38 ± 0.42
8.60 ± 0.46
8.63 ± 0.55
Fasting blood insulin (ng/mL)
0.84 ± 0.02
0.97 ± 0.02*
0.87 ± 0.01
0.85 ± 0.03△
AUCI0-5 ((ng/mL) * min)
9.65 ± 0.13
9.31 ± 0.06*
9.58 ± 0.15
7.40 ± 0.15*#△
AUCI0-30 ((ng/mL) * min)
43.82 ± 0.21
61.61 ± 0.56*
44.31 ± 0.31
44.93 ± 0.71△
WT: wild type mice; WH: wild type mice with high-fat diet; KO: ACE2 knockout mice; KH: ACE2 knockout mice with high-fat diet, versus WT *, versus KO #, and versus WH △.
