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Journal of Diabetes Research
Volume 2013, Article ID 452537, 5 pages
http://dx.doi.org/10.1155/2013/452537
Clinical Study

Association of the HLA-DQA1 and HLA-DQB1 Alleles in Type 2 Diabetes Mellitus and Diabetic Nephropathy in the Han Ethnicity of China

2011 Collaborative Innovation Center of Tianjin for Medical Epigenetics, Key Laboratory of Hormone and Development (Ministry of Health), Metabolic Disease Hospital & Tianjin Institute of Endocrinology, Tianjin Medical University, Tianjin 300070, China

Received 1 January 2013; Revised 29 January 2013; Accepted 29 January 2013

Academic Editor: Weiping Jia

Copyright © 2013 Ze-Jun Ma et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

HLA gene system is one of the most polymorphic regions of the human genome. The association of HLA class II genes in T1DM pathogenesis has been reported for several ethnicities. Associations of HLA class II genes with T2DM have revealed inconsistent results. Moreover, correlations between DN and HLA alleles remain unclear. We carried out DNA typing chip by specific medium resolution typing probes in 310 T2DM subjects (including 210 patients with DN and 100 patients without DN) in addition to 100 healthy controls. Differences were found between patients with T2DM and the control group in the frequencies of the HLA-DQA1*0301 (15.5% versus 8.0%, ) and the HLA-DQA1*0501 alleles (16.6% versus 8.5%, ). Differences were found between patients with DN and without DN in the frequencies of the HLA-DQA1*0302 (6.9% versus 13.5%, ) and HLA-DQB1*0501 alleles (5.8% versus 14.5%, ). Diabetes duration and systolic blood pressure were independent risk factors associated with DN ( and 1.366, resp., ), whereas the HLA-DQB1*0501 llele had a protective effect on DN ( , ). These data suggest the HLA-DQA1*0301 and HLA-DQA1*0501 alleles are markers of susceptibility for T2DM, and the HLA-DQB1*0501 allele is associated with a protective effect on DN in Han ethnicity of China.