Advanced Diabetic Nephropathy with Nephrotic Range Proteinuria: A Pilot Study of the Long-Term Efficacy of Subcutaneous ACTH Gel on Proteinuria, Progression of CKD, and Urinary Levels of VEGF and MCP-1

<table>Whisker box plots of 24-hour urinary protein (grams/24 hrs) response for the 16- and 32-unit ACTH groups. A significant reduction in proteinuria is noted for the 16-unit dose at 6 months with a trend toward additional reduction in proteinuria 6 months after withdrawing ACTH. No effect is seen with the 32-unit ACTH dose.</table>

Journal of Diabetes Research

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Figure 3: Advanced Diabetic Nephropathy with Nephrotic Range Proteinuria: A Pilot Study of the Long-Term Efficacy of Subcutaneous ACTH Gel on Proteinuria, Progression of CKD, and Urinary Levels of VEGF and MCP-1 

Figure 3 | Advanced Diabetic Nephropathy with Nephrotic Range Proteinuria: A Pilot Study of the Long-Term Efficacy of Subcutaneous ACTH Gel on Proteinuria, Progression of CKD, and Urinary Levels of VEGF and MCP-1 