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Journal of Diabetes Research
Volume 2013 (2013), Article ID 561016, 7 pages
http://dx.doi.org/10.1155/2013/561016
Research Article

Adipocytokine Associations with Insulin Resistance in British South Asians

1Department of Cardiovascular Sciences, University of Leicester, Leicester LE3 9QP, UK
2Leicester Diabetes Center, Leicester General Hospital, Ward 5 (Broadleaf), Gwendolen Road, Leicester LE5 4PW, UK
3Department of Health Sciences, University of Leicester, Leicester LE1 6TP, UK
4Buckinghamshire Hospitals NHS Trust, Buckinghamshire HP7 OJD, UK

Received 16 August 2012; Accepted 17 December 2012

Academic Editor: N. Sattar

Copyright © 2013 D. R. Webb et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Aims. Adipocytokines are implicated in the pathogenesis of type 2 diabetes and may represent identifiable precursors of metabolic disease within high-risk groups. We investigated adiponectin, leptin, and TNF-α and assessed the contribution of these molecules to insulin resistance in south Asians. Hypothesis. South Asians have adverse adipocytokine profiles which associate with an HOMA-derived insulin resistance phenotype. Methods. We measured adipocytokine concentrations in south Asians with newly diagnosed impaired glucose tolerance or Type 2 Diabetes Mellitus in a case-control study. 158 (48.5% males) volunteers aged 25–75 years with risk factors for diabetes but no known vascular or metabolic disease provided serum samples for ELISA and bioplex assays. Results. Total adiponectin concentration progressively decreased across the glucose spectrum in both sexes. A reciprocal trend in leptin concentration was observed only in south Asian men. Adiponectin but not leptin independently associated with HOMA-derived insulin resistance after logistic multivariate regression. Conclusion. Diasporic south Asian populations have an adverse adipocytokine profile which deteriorates further with glucose dysregulation. Insulin resistance is inversely associated with adiponectin independent of BMI and waist circumference in south Asians, implying that adipocytokine interplay contributes to the pathogenesis of metabolic disease in this group.