The Effect of Diabetes-Associated Autoantigens on Cell Processes in Human PBMCs and Their Relevance to Autoimmune Diabetes Development
Table 3
(a) GeneGo pathway top 10 maps (“immune response pathways” are in bold). (b) The complete list of significant “immune response pathways” for each pair comparison; pathway rankings (the position of each pathway within the list) are indicated.
(a)
T1D (D) patients versus healthy controls (DV)
Relatives of T1D patients (DRL) versus healthy controls (DV)
T1D (D) patients versus relatives of T1D patients (DRL)
(1) Immune response_Antigen presentation by MHCII (2) G protein signalling_Rac3 regulation pathway (3) Neurophysiological process_Olfactory transduction (4) Transcription_CREM signalling in testis (5) Dichloroethylene metabolism (6) Delta508-CFTR traffic/sorting endosome formation in CF (7) Immune response_Th17 cell differentiation (8) G-protein signalling_Regulation of CDC42 activity (9) Immune response_IL-22 signalling pathway (10) Development_BMP signalling
(1) Immune response_MIF-JAB1 signalling (2) Cytoskeleton remodeling_Fibronectin bindings integrins in cell motility (3) Translation_(L)-selenoaminoacids incorporation in proteins during translation (4) Regulation of lipid metabolism_Insulin regulation of glycogen metabolism (5) Glutathione metabolism (6) Development_Ligand-dependent activation of the ESR1/AP1 pathway (7) G protein signalling_Rac3 regulation pathway (8) Protein folding_Membrane trafficking and signal transduction of G-alpha (9) Neurophysiological process_Olfactory transduction (10) Dichloroethylene metabolism
(1) Cytoskeleton remodeling_CDC42 in cellular processes (2) Development_BMP signalling (3) Neurophysiological process_EphB receptors in dendritic spine morphogenesis and synaptogenesis (4) Development_Hedgehog signalling (5) Neolacto-series GSL Metabolism p.2 and p.3 (6) Neurophysiological process_Olfactory transduction (7) Atherosclerosis_Role of ZNF202 in regulation of expression of genes involved in Atherosclerosis (8) Dichloroethylene metabolism (9) Cytoskeleton remodeling_Neurofilaments (10) Triacylglycerol metabolism p.2
(b)
T1D (D) patients versus healthy controls (DV)
Relatives of T1D patients (DRL) versus healthy controls (DV)
T1D (D) patients versus relatives of T1D patients (DRL)
1: Antigen presentation by MHCII 7: Th17 cell differentiation 9: IL-22 signalling pathway 20: TCR and CD28 costimulation in activation of NF-kB 23: Th1 and Th2 cell differentiation 25: HTR2A induced activation of cPLA2 28: IL-13 signalling via JAK-STAT 32: Lectin induced complement pathway 33: Development of TGF-beta receptor signalling 35: T cell receptor signalling pathway 41: Immunological synapse formation
1: MIF-JAB1 signalling 27: CXCR4 signalling via second messenger 28: CXCR4 signalling pathway 32: Regulation of T cell function by CTLA-4 36: IL-7 signalling in T lymphocytes 43: IL-7 signalling in B lymphocytes 53: T cell receptor signalling pathway 55: CD28 signalling 56: Role of DAP12 receptor in NK cells 59: Immunological synapse formation
24: Cytokine production by Th17 cells 31: TGF-beta receptor signalling 36: Th17 signalling pathway 40: Gastrin in inflammatory response
