Deoxycholic Acid as a Modifier of the Permeation of Gliclazide through the Blood Brain Barrier of a Rat

Table 1

Gliclazide concentrations (𝜇g/g) 240 seconds after gliclazide injection (20 mg/kg) in the brain parts and total brain.

Groups		Group 1: healthy Gliclazide; 𝑛=6	Group 2: healthy Gliclazide + DA; 𝑛=6	Group 3: diabetic Gliclazide; 𝑛=6	Group 4: diabetic Gliclazide + DA 𝑛=6
Gliclazide concentration; (𝜇g/g)—mean ± SD	BS	1.57±0.77	15.49±9.53^∗	11.51±5.48^#	33.72±19.58^××,×
	C	2.22±1.13	23.69±11.45^∗	19.17±8.18^#	76.92±34.82^××,##
	LCH	1.41±0.75	1.87±0.94	0.70±0.38	6.93±4.09^××,×
	RCH	2.46±1.56	6.33±4.03^∗	2.88±1.30	10.02±6.43^××,×
	B	1.71±1.03	9.15±5.53^∗	7.27±3.41^#	22.00±14.15^××,×

LCH: left cerebral hemisphere; RCH: right cerebral hemisphere; BS: brain stem; C: cerebellum, B: total brain.
*Group 2 versus Group 1, 𝑃≤0.05; ^#Group 3 versus Group 1, 𝑃≤0.05; ^×Group 4 versus Group 3, 𝑃≤0.05; ^##Group 4 versus Group 2, 𝑃≤0.05; ^××Group 4 versus Group 1, 𝑃≤0.05.