Dose Effect and Mode of Inheritance of Diabetogenic Gene on Mouse Chromosome 11

Figure 2

Streptozotocin sensitivity at 12 weeks of age in heterozygous C3H-11^NSY (𝑛=20, white triangles), C3H mice (𝑛=20; white circles), and homozygous C3H-11^NSY (𝑛=23, black circles, [7]). The glucose concentration was determined 0, 1, 2, 4, 5, 7, and 8 days after a single intraperitoneal injection of streptozotocin at 175 mg/kg body weight. Blood glucose concentrations are presented as mean ± SEM (a). The percentage of animals free of hyperglycemia (blood glucose level >11.1 mmol/L) is shown (b). *𝑃<0.05, **𝑃<0.01, and ***𝑃<0.001 compared with C3H and ^†𝑃<0.05, ^††𝑃<0.01, and ^†††𝑃<0.001 compared with heterozygous C3H-11^NSY (Mann-Whitney 𝑈 test for (a), log-rank test for (b)).

(a)

(b)