Dose Effect and Mode of Inheritance of Diabetogenic Gene on Mouse Chromosome 11

Table 1

Insulin secretion and insulin resistance at 52 weeks of age.

		C3H (𝑛=8)	C3H-11^NSY; (heterozygotes); (𝑛=8)	C3H-11^NSY; (homozygotes)^†; (𝑛=26)
Blood glucose
0 min	(mmol/L)	5.6 ± 0.3	5.8 ± 0.4	6.3 ± 0.3
15 min	(mmol/L)	17.3 ± 0.6	20.7 ± 2.9	18.1 ± 0.5
30 min	(mmol/L)	19.7 ± 1.9	23.4 ± 2.8	22.8 ± 0.5
ΣΔgAUC	(pmol/L × min)	281.7 ± 19.6	356.1 ± 57.7	300.2 ± 9.3
Insulin
0 min	(pmol/L)	19.6 ± 5.3	31.7 ± 7.6	25.7 ± 2.7
15 min	(pmol/L)	140.1 ± 16.9	112.7 ± 12.9	106.1 ± 8.4
30 min	(pmol/L)	78.7 ± 8.1	88.1 ± 10.7	84.8 ± 5.7
ΣΔiAUC	(pmol/L × min)	2249.8 ± 252.6	1639.8 ± 324.4	1649.0 ± 140.3
Insulin secretion^††		8.6 ± 1.5	5.8 ± 1.5	5.6 ± 0.5
Insulin sensitivity^†††		118.7 ± 39.9	201.2 ± 56.9	168.4 ± 20.9

Values are total number or mean ± SEM. Heterozygous C3H-11^NSY were compared with C3H and homozygous C3H-11^NSY by Mann-Whitney U test, but no significant difference was observed. ^†Data of homozygous C3H-11^NSY mice were already reported [6]. ^††Assessed by insulinogenic index (incremental AUC (ΣΔiAUC), (pmol/L) divided by incremental glucose AUC (ΣΔgAUC), (mmol/L)) during ipGTT. ^†††Assessed by HOMA-IR: calculated from basal insulin and glucose concentrations (fasting glucose (mmol/L) × fasting insulin (pmol/L)).