Dose Effect and Mode of Inheritance of Diabetogenic Gene on Mouse Chromosome 11

Table 2

Anatomical analysis at 54 weeks of age.

		C3H (𝑛=8)	C3H-11^NSY; (Heterozygous); (𝑛=8)	C3H-11^NSY; (Homozygous)^†; (𝑛=26)
Blood glucose (ad lib)	(mmol/L)	6.7 ± 0.4	7.4 ± 0.5	8.1 ± 0.2
Insulin (ad lib)	(pmol/L)	135.9 ± 12.3	172.4 ± 16.5	226.0 ± 12.8
Body weight	(g)	31.4 ± 0.8	29.6 ± 0.8	31.0 ± 0.5
Liver	(g)	1.549 ± 0.100	1.529 ± 0.045	1.409 ± 0.039
Total fat	(g)	1.065 ± 0.109	1.024 ± 0.070	1.209 ± 0.072
Epididymal fat	(g)	0.522 ± 0.068	0.527 ± 0.042	0.707 ± 0.054
Mesenteric fat	(g)	0.543 ± 0.065	0.497 ± 0.035	0.502 ± 0.021
Total fat/body weight	(%)	3.37 ± 0.29	3.44 ± 0.18	3.87 ± 0.19

Values are total number or mean ± SEM. Heterozygous C3H-11^NSY were compared with C3H and homozygous C3H-11^NSY by Mann-Whitney U test, but no significant difference was observed. ^†Data of homozygous C3H-11^NSY mice were already reported [6].