Nearby Construction Impedes the Progression to Overt Autoimmune Diabetes in NOD Mice

Figure 1

Nearby construction during the gestation period impacts diabetes onset and cumulative incidence in offspring. Depicted is a typical cumulative incidence of diabetes for eighteen female NOD/LtJ-HMR mice (open squares). Two NOD/LtJ-HMR female mice were in gestation while asphalt and sidewalk repairs were being carried out immediately outside the facility. The incidence of diabetes was closely monitored in the seven female offspring from these mothers (closed circles), where the onset is observed at 22 weeks of age and the cumulative incidence reaches approximately 30% at 32 weeks of age. Log-rank test, 𝑃 value < 0.05.