Postulated Tregitope mechanism of action. Tregitopes are highly conserved Treg epitopes found in human and other species’ IgG. They are postulated to reduce the immunogenicity of neo-epitopes in the hypervariable region of IgG CDR; they also suppress immune response to other co-delivered T cell epitopes. (A version of this figure was originally published in Blood. De Groot A. S., Moise L., McMurry J. A., Wambre E., Van Overvelt L., Moingeon P., Scott W., Martin W. Activation of natural regulatory T cells by IgG Fc-derived peptide “Tregitopes”. Blood 2008; 112 : 3303.)