Application of IgG-Derived Natural Treg Epitopes (IgG Tregitopes) to Antigen-Specific Tolerance Induction in a Murine Model of Type 1 Diabetes
Figure 3
GAD65 450–470 and 550–570 cluster maps. EpiMatrix-predicted 9-mer hits for eight prevalent HLA class II alleles are shown in the cluster map under each allele for two example GAD 65 peptide sequences. Any 9-mer peptide scoring above 1.64 on the EpiMatrix “Z” scale (top 5%) is considered to be a potential epitope (blue bars) or “hit.” Peptides scoring above 2.32 on the scale (top 1%) are extremely likely to bind MHC (dark blue bars). The 450–470 cluster contains three 9-mers with multiple positive scores. Hits across four or more HLA class II alleles constitute an EpiBar. The GAD65 450–470 cluster contains three EpiBars; the 550–570 cluster contains a single EpiBar (highlighted in yellow).
