Application of IgG-Derived Natural Treg Epitopes (IgG Tregitopes) to Antigen-Specific Tolerance Induction in a Murine Model of Type 1 Diabetes

Figure 5

Study 2—prevention of T1D in NOD mice using Tregitopes. When co-administered with the “target” antigen (five murine preproinsulin or mPPI peptides) in liposomes, treatment with four Tregitope peptides (mouse 167 and 289 and human 167 and 289) completely suppressed the development of T1D in NOD mice. Arrows represent time points when treatments were administered. Black symbols represent groups receiving Tregitopes with (circle) or without (square) target antigen. White circles represent the vehicle control group. Antigen peptides alone are indicated by white triangles, and antigen peptides with an irrelevant MHC-binding peptide by gray circles. Mice receiving liposomes alone (white circles) had a 67% incidence of diabetes at 20 weeks of age compared to 38% in mice receiving Tregitopes alone (black square). None of the mice receiving Tregitopes with antigen (black circles) developed diabetes.